Paolo Sassone-Corsi, Ph.D.
During the past three decades, Dr. Sassone-Corsi’s research has focused on unraveling how epigenetics is critical for healthy lifespan, wellbeing, appropriate circadian and sleep cycles, aging and prevention of disease.
Research conducted in the Sassone-Corsi Laboratory has significantly impacted the fields of epigenetics, metabolism and endocrinology. The high impact of his team’s research is witnessed by the numerous high-profile publications (he’s among the very exclusive group of ‘most cited’), invitations as plenary speaker at high-profile conferences, and a long list of international, prestigious scientific awards.
Some of Dr. Sassone-Corsi’s most notable research has revealed how nutritional challenges reprogram circadian homeostasis and revealed previously unforeseen pathways of circadian control that connect to nutrition, cancer and aging. These studies provide new leads towards therapeutic strategies for metabolic disorders.
Emiliana Borrelli, Ph.D.
Dr. Borrelli is a prominent molecular and cellular neurobiologist who has pioneered the use of genetically engineered animals to reveal mechanisms of behavior, drugs of abuse and neuropsychiatric disorders. She has dedicated her career to the study of dopamine signaling in health and disease.
Research in the Borrelli Laboratory has demonstrated the importance of dopamine D2 receptors in dopamine-dependent disorders such as Parkinson’s Disease. She achieved this goal through analyses of mouse models genetically modified for the expression of the dopamine receptors. Recent studies are elucidating the role played by dopamine in eliciting epigenetic modifications in specific brain areas.
Dr. Borrelli’s achievements have allowed the elucidation of a remarkable variety of molecular mechanisms, relevant to the fields of neurology, psychiatry and neuroendocrinology. In this respect, her work on the regulation of signal transduction by dopamine represents a notable paradigm. Her most recent discoveries include mechanisms governing dopamine mediated brain circuits relevant to neuropsychiatric disorders and addiction.